Tumor RNA from an FFPE block or at least 10 unstained 10 µm slides with at least 20% tumor content; exact RNA quality and quantity are confirmed.
TUMOR DIAGNOSTICS
CancerFusionRx
Targeted RNA enrichment for oncogenic fusions, including exon-skipping events and activating transcript alterations that can be difficult to resolve from DNA alone.
Targeted RNA fusion sequencing across more than 200 genes and more than 130 enriched exon–exon breakpoint regions, including known and novel partners.
Fusion partners, functional class, transcript identifiers, predicted protein effect, and potentially eligible medicines where supported.
Confirmed after RNA quality and pathology review.
CLINICAL VALUE
Where this test is strongest
✓More than 200 fusion genes
✓Known and novel fusion partners
✓More than 130 enriched exon–exon breakpoints
✓Includes MET exon 14 skipping and activating EGFR deletions
✓Selected oncogenic infection screen
LIMITATIONS
What must remain visible
!Requires sufficient, representative tumor RNA.
!A negative result does not exclude all structural or transcriptional alterations.
GENE & ANALYTICAL SCOPE
219 published genes
The complete targeted RNA gene list is searchable below.
RNA fusion targets219 published genes+
Complete >200-gene targeted fusion scope.
ABL1ACTBADGRG7AFAP1AFF2AGKAKAP4AKAP9AKAP12AKT1AKT2AKT3ALKARHGAP6ARHGAP26ASPSCR1ATF1ATP1B1ATRXAVILAXLBAG4BCL2BCORBCORL1BCRBEND2BICC1BRAFBRD3BRD4CAMTA1CCAR2CCDC6CCDC88ACCDC170CCNB3CCND1CD44CD74CEP85LCICCLDN18CLIP1CLTCCNTRLCOL1A1CREB1CREB3L1CREB3L2CREMCRTC1CTNNB1DDIT3DNAJB1EGFREML4EPC1EPCAMERBB2ERBB4ERGESR1ESRRAETV1ETV4ETV5ETV6EWSR1EZHIPEZRFEVFGFR1FGFR2FGFR3FGFR4FLI1FN1FOXO1FOXO4FOXR2FUSGLI1GOPCHEY1HMGA2HTRA1IGF1RINSRJAK2JAZF1KIAA1549KIF5BKITLEUTXLMNALPPLTKMAGI3MAML1MAML2MAML3MAMLD1MAP3K8MARS1MAST1MAST2MEAF6METMGAMGMTMITFMN1MRTFBMSH2MYBMYBL1MYCNAB2NCOA1NCOA2NCOA3NCOA4NFATC2NFIBNOTCH2NPM1NR4A3NRG1NRG2NSD3NTRK1NTRK2NTRK3NUTM1PAX3PAX7PAX8PBX1PDGFBPDGFDPDGFRAPDGFRBPHF1PIK3CAPLAG1PMLPOU5F1PPARGPPARGC1APPP1CBPRKACAPRKAR1APRKCAPRKCBPRKD1PRKD2PRKD3PTPRZ1QKIRAD51BRAF1RANBP2RARARELARELCHRETROS1RPS6KB1RREB1RSPO2RSPO3SDC1SDC4SH3PXD2ASLC1A2SHTN1SLC34A2SLC44A1SLC45A3SND1SQSTM1SS18SSX1SSX2SSX4ST7STAT6STRNSUZ12TACC1TACC2TACC3TAF15TCF3TCF12TERTTFE3TFEBTFGTHADATMPRSS2TPM3TPRTRIM24TRIM33TRIOTTYH1VGLL2VGLL3VMP1WT1WWTR1YAP1YWHAEZC3H7BZFTAZMYM2ZNF703
Infection screenCase-specific analytical scope+
HPV, EBV, MCV, CMV, H. pylori, HBV, and HCV in the referenced workflow.
No fixed gene-by-gene list applies to this scope.
BEFORE ORDERING
Confirm the current laboratory specification.
The official case review and quotation confirm eligibility, accepted material, validated coverage and variant classes, consent, turnaround, price, and report pathway.